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UR-144 has high affinity for the CB2 receptor with a Ki of 1.8 nM but 83x lower affinity for the CB1 receptor with a Ki of Associate in Nursingd fifty} nM. it absolutely was found to possess an EC50 of 421 nM for human CB1 receptors, and seventy two nM for human CB2 receptors. UR-144 produces arrhythmia and physiological state in rats at a dose of ten mg\/kg, suggesting weak cannabinoid-like activity.<\/p>\n

with chemicals it\u2019s closely concerning alternative 2,2,3,3-tetramethylcyclopropyl artificial cannabinoids like A-796,260 and A-834,735 however with a special substitution on the 1-position of the indole core, in these compounds its 1-pentyl cluster is replaced with\u00a0alkylheterocycles\u00a0like 1-(2-morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).<\/p>\n

Chemical and physical information
Formula: C21H29NO<\/p>\n

Molar mass: 311.461 g\/mol g\u00b7mol?1<\/p>\n

Dose<\/strong>
Inhalation (tentative because of an absence of information)<\/p>\n

Range: 2.5 to twenty mg<\/strong>
the general public are exposed to the drug within the type of \u0093blends\u0094 that contain variable levels of UR-144. It\u0092s not informed use those products.<\/p>\n

Timeline<\/strong>
Inhalation (tentative because of an absence of information)
Total: one \u0096 two hours
Onset: below ten minutes
see
AB-001
AM-1221
4-HTMPIPO
FAB-144
JTE 7-31
JWH-018
N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide
XLR-11<\/p>","protected":false},"excerpt":{"rendered":"

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